Novel strategy for activating gene expression through triplex DNA formation targeting epigenetically suppressed genes-Reference-Cited by-同舟云学术

Novel strategy for activating gene expression through triplex DNA formation targeting epigenetically suppressed genes

Published:2024 Issue:9 Volume:5 Page:884-890
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Notomi Ryotaro¹,Sasaki Shigeki²^ORCID,Taniguchi Yosuke³¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

2. Graduate School of Pharmaceutical Sciences, Nagasaki International University, 22825-7 Huis Ten Bosch Machi, Sasebo city, Nagasaki 859-3298, Japan

3. Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

Abstract

Gene transcription is activated by forming triplex DNA on the methylated dC-containing promoter sequence of the gene whose transcription was suppressed.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Japan Science and Technology Corporation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D4CB00134F

Reference66 articles.

1. Mechanisms of triplex DNA-mediated inhibition of transcription initiation in cells

2. Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells

3. Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells

4. Inhibition of transcription and antiproliferative effects in a cancer cell line using antigene oligonucleotides containing artificial nucleoside analogues

5. Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications