Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands-Reference-Cited by-同舟云学术

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands

Published:2019 Issue:12 Volume:10 Page:2052-2072
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Blaikie Laura¹²³⁴,Kay Graeme¹²³⁴,Kong Thoo Lin Paul¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy and Life Sciences

2. Robert Gordon University

3. Aberdeen

4. UK

Abstract

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. Since AD is a multi-factorial disease, a MTDL approach to drug discovery is discussed.

Funder

Carnegie Trust for the Universities of Scotland

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00337A

Reference118 articles.

1. Current and future treatments for Alzheimer’s disease

2. From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease

3. M. Prince , M.Knapp , M.Guerchet , P.McCrone , M.Prina , A.Comas-Herrera , R.Wittenberg , B.Adelaja , B.Hu , D.King , A.Rehill and D.Salimkumar , Alzheimer's Society , 2014 , vol. 2 , pp. 1–62

4. F. Lewis , S. K.Schaffer and J.Sussex , Alzheimer's Research UK , 2014 , vol. 1 , pp. 1–62

5. The Treatment Strategies for Neurodegenerative Diseases by Integrative Medicine

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