Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip-Reference-Cited by-同舟云学术

Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip

Published:2022 Issue:23 Volume:22 Page:4469-4480
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ioannidis Konstantinos¹^ORCID,Cohen Aaron¹²^ORCID,Ghosheh Mohammad¹²,Ehrlich Avner¹²³^ORCID,Fischer Amit⁴,Cohen Merav¹²^ORCID,Nahmias Yaakov¹²³^ORCID

Affiliation:

1. Grass Center for Bioengineering, Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

2. Department of Cell and Developmental Biology, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

3. Tissue Dynamics, Jerusalem 91904, Israel

4. Department of Biological Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

Abstract

Vascularized model of human kidney on chip utilizes tissue-embedded sensors to reveal the metabolic signature of aminoglycosides toxicity. Data shows gentamicin-induced injury is driven lipotoxicity, which can be blocked by empagliflozin.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D2LC00825D

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5. Role of megalin in renal handling of aminoglycosides

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