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New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters

  • Published:2016 Issue:2 Volume:33 Page:174-182
  • ISSN:0265-0568
  • Container-title:Natural Product Reports
  • language:en
  • Short-container-title:Nat. Prod. Rep.

Author:

Luo Yunzi12345,Enghiad Behnam6789,Zhao Huimin678910

Affiliation:

1. State Key Laboratory of Biotherapy

2. West China Hospital

3. Sichuan University and Collaborative Innovation Center of Biotherapy

4. Chengdu

5. P. R. China

6. Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology

7. University of Illinois at Urbana-Champaign

8. Urbana

9. USA

10. Departments of Chemistry

Abstract

Here we describe recent advances in DNA assembly and host engineering and highlight their applications in natural product discovery and engineering.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference53 articles.

1. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

2. Recent advances in natural product discovery

3. Engineered biosynthesis of natural products in heterologous hosts

4. R. E. Cobb , Y.Luo, T.Freestone and H.Zhao, Drug Discovery and Development via Synthetic Biology, Elsevier, San Diego, CA, 2013

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