Spiroconyone A, a new phytosterol with a spiro [5,6] ring system from Conyza japonica-Reference-Cited by-同舟云学术

Spiroconyone A, a new phytosterol with a spiro [5,6] ring system from Conyza japonica

Published:2020 Issue:27 Volume:18 Page:5130-5136
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xiao Long-Gao¹²³⁴^ORCID,Zhang Yu¹²³⁴,Zhang Hong-Li¹²³⁴^ORCID,Li Ding¹²³⁴^ORCID,Gu Qiong¹²³⁴^ORCID,Tang Gui-Hua¹²³⁴^ORCID,Yu Qian¹²³⁴⁵,An Lin-Kun¹²³⁴⁶^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Sun Yat-sen University

3. Guangzhou

4. China

5. Clinical Pharmacy (School of Integrative Pharmacy

6. Guangdong Provincial Key Laboratory of New Drug Design and Evaluation

Abstract

The first rearranged phytosterol (spiroconyone A) with an unusual spiro [5,6] ring system and two new TDP1 inhibitors 7 and 10 showing a strong synergistic effect with topotecan were isolated from Conyza japonica.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00666A

Reference36 articles.

1. The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

2. A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.

3. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer