Interplay of chloride levels and palladium(<scp>ii</scp>)-catalyzed <i>O</i>-deallenylation bioorthogonal uncaging reactions-Reference-Cited by-同舟云学术

Interplay of chloride levels and palladium(ii)-catalyzed O-deallenylation bioorthogonal uncaging reactions

Published:2024 Issue:12 Volume:15 Page:4458-4465
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Dal Forno Gean M.¹^ORCID,Latocheski Eloah¹^ORCID,Navo Claudio D.²^ORCID,Albuquerque Brunno L.¹^ORCID,St John Albert L.¹,Avenier Frédéric³^ORCID,Jiménez-Osés Gonzalo²⁴^ORCID,Domingos Josiel B.¹^ORCID

Affiliation:

1. Laboratory of Biomimetic Catalysis (LaCBio), Department of Chemistry, Federal University of Santa Catarina (UFSC), Campus Trindade, Florianópolis, 88040-900, SC, Brazil

2. Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, Derio, 48160, Spain

3. Institut de Chimie Moléculaire et des Matériaux d’Orsay (UMR 8182), Université Paris Saclay, 9140, Orsay Cedex, France

4. Ikerbasque, Basque Foundation for Science, 48013, Bilbao, Spain

Abstract

Palladium-mediated C–O bond cleavage in deallenylation shows higher rates at low chloride levels, akin to intracellular conditions, versus reduced efficiency in high chloride concentration, similar to extracellular settings.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Agencia Estatal de Investigación

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Laboratório Nacional de Luz Síncrotron

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC06408E

Reference39 articles.

1. Unleashing the Power of Bond Cleavage Chemistry in Living Systems

2. Transition metal catalysts for the bioorthogonal synthesis of bioactive agents

3. Exporting Homogeneous Transition Metal Catalysts to Biological Habitats

4. Inorganic nanoparticles as scaffolds for bioorthogonal catalysts

5. Bioorthogonal catalysis in complex media: Consequences of using polymeric scaffold materials on catalyst stability and activity