A thermoresponsive gel photoreleasing nitric oxide for potential ocular applications

Author:

Seggio Mimimorena1234,Tessaro André Luiz56789,Nostro Antonia1011121314,Ginestra Giovanna1011121314,Graziano Adriana C. E.15163174,Cardile Venera15163174,Acierno Stefano1819204,Russo Pietro212223244,Catanzano Ovidio252627284ORCID,Quaglia Fabiana252627284ORCID,Sortino Salvatore1234ORCID

Affiliation:

1. PhotoChemLab

2. Department of Drug Sciences

3. University of Catania

4. Italy

5. Nucleus of Industrial Innovation

6. Federal University of Technology – Paraná (UTFPR)

7. UTFPR

8. Apucarana

9. Brazil

10. Department of Chemical

11. Biological

12. Pharmaceutical and Environmental Sciences

13. University of Messina

14. Messina

15. Department of Bio-Medical and Biotechnological Sciences

16. Physiology Division

17. I-95125 Catania

18. Department of Engineering

19. University of Sannio

20. Benevento

21. Institute for Polymers

22. Composites and Biomaterials

23. National Council of Research

24. Pozzuoli (Na)

25. Drug Delivery Laboratory

26. Department of Pharmacy

27. University of Napoli Federico II

28. Napoli

Abstract

A thermoresponsive gel integrating a NO photodonor shows physico-chemical stability in simulated tear fluid, releases NO under daylight conditions, is well tolerated by corneal cells and exhibits photobactericidal action towards Staphylococcus aureus.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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