STS loaded PCL-MECM based hydrogel hybrid scaffolds promote meniscal regeneration via modulating macrophage phenotype polarization

Author:

Li Muzhe12,Yin Han1,Chen Mingxue3,Deng Haotian1,Tian Guangzhao1,Guo Weimin4,Yi Guoliang2,Guo Quanyi1ORCID,Chen Zhiwei2,Liu Shuyun1ORCID

Affiliation:

1. Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China

2. Department of Orthopedics, The First Affiliated Hospital, Hengyang Medical School, University of South China, No. 69, Chuanshan Road, Hengyang 421000, Hunan Province, China

3. Department of Orthopedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing 100035, China

4. Department of Orthopaedic Surgery, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan Second Road, Yuexiu District, Guangzhou 510080, Guangdong, China

Abstract

STS loaded PCL-MECM based hydrogel hybrid scaffold seeded with MFCs could achieve good meniscus regeneration and chondroprotective effects in the rabbit.

Funder

Health Commission of Hunan Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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