Development of a 3D printed perfusable <i>in vitro</i> blood–brain barrier model for use as a scalable screening tool-Reference-Cited by-同舟云学术

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Development of a 3D printed perfusable in vitro blood–brain barrier model for use as a scalable screening tool

Published:2024 Issue:17 Volume:12 Page:4363-4375
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Royse Madison K.¹,Fowler Martha¹,Mai A. Kristen¹^ORCID,He Yufang²^ORCID,Durante Marc R.²,Buist Nicole³,Procopio Adam³,Xu Jun³^ORCID,Veiseh Omid¹^ORCID

Affiliation:

1. Department of Bioengineering, Rice University, 6100 Main St., Houston, TX 77005, USA

2. Division of Technology, Infrastructure, Operations & Experience, Merck & Co., Inc. Rahway, NJ 07065, USA

3. Department of Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc. Rahway, NJ 07065, USA

Abstract

A 3D printed hydrogel optimized for a BBB model (1) and evaluated for perfusion and ultrasound assisted transport of antibody, IgG, across the BBB (2).

Funder

Merck Sharp and Dohme United Kingdom

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D4BM00663A

Reference53 articles.

1. Biology and Models of the Blood–Brain Barrier

2. 3D in vitro modeling of the central nervous system

3. Microfluidic organ-on-chip technology for blood-brain barrier research

4. Reproducing human and cross-species drug toxicities using a Liver-Chip

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