Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents

Published:2015 Issue:26 Volume:5 Page:19944-19954
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Di Bussolo Valeria¹²³⁴,Calvaresi Emilia C.⁵⁶⁷⁸,Granchi Carlotta¹²³⁴,Del Bino Linda¹²³⁴,Frau Ileana¹²³⁴,Dasso Lang Maria Chiara¹²³⁴,Tuccinardi Tiziano¹²³⁴,Macchia Marco¹²³⁴,Martinelli Adriano¹²³⁴,Hergenrother Paul J.⁵⁶⁷⁸,Minutolo Filippo¹²³⁴

Affiliation:

1. Dipartimento di Farmacia

2. Università di Pisa

3. 56126 Pisa

4. Italy

5. Department of Chemistry

6. University of Illinois

7. Urbana

8. USA

Abstract

Conjugation of N-hydroxyindole (NHI)-based LDH inhibitors to monosaccharide portions reveals that, among this series, α-d-mannose-NHI conjugate possesses the best properties in cancer cellular assays in terms of both antiglycolytic and antiproliferative activity.

Funder

National Institutes of Health

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA00946D

Reference26 articles.

1. The Warburg Effect Revisited-Lesson from the Sertoli Cell

2. Anticancer Agents That Counteract Tumor Glycolysis