Development of small cyclic peptides targeting the CK2α/β interface-Reference-Cited by-同舟云学术

Development of small cyclic peptides targeting the CK2α/β interface

Published:2022 Issue:30 Volume:58 Page:4791-4794
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Atkinson Eleanor L.¹^ORCID,Iegre Jessica¹^ORCID,D’Amore Claudio²,Brear Paul³^ORCID,Salvi Mauro²^ORCID,Hyvönen Marko³^ORCID,Spring David R.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK

2. Department of Biomedical Sciences, University of Padova, Padova, Italy

3. Department of Biochemistry, University of Cambridge, Tennis Court Road, CB2 1GA, Cambridge, UK

Abstract

Development of a small CK2α/β protein–protein interaction-inhibiting peptide, which is easily synthesisable and functionalisable, with good enzymatic and cellular activity.

Funder

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC00707J

Reference20 articles.

1. How can a traffic light properly work if it is always green? The paradox of CK2 signaling

2. Chemical probes targeting the kinase CK2: a journey outside the catalytic box

3. CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

4. Protein kinase CK2 and its role in cellular proliferation, development and pathology

5. Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2β interaction

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