Total chemical synthesis of lassomycin and lassomycin-amide
Author:
Affiliation:
1. Department of Chemistry
2. Durham University
3. Durham
4. UK
5. St. George's University of London
6. London
7. Department of Biological Chemistry and Molecular Pharmacology
8. Harvard Medical School
9. Boston
10. USA
Abstract
Herein we report a practical synthetic route to the lasso peptide lassomycin (1) and C-terminal variant lassomycin-amide (2).
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00631K
Reference24 articles.
1. Antibiotics for Emerging Pathogens
2. From magic bullets back to the Magic Mountain: the rise of extensively drug-resistant tuberculosis
3. Isolating "Uncultivable" Microorganisms in Pure Culture in a Simulated Natural Environment
4. Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
5. The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring
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