Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination-Reference-Cited by-同舟云学术

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination

Published:2017 Issue:1 Volume:8 Page:202-210
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sokias Renee¹²³,Werry Eryn L.⁴²⁵³⁶,Chua Sook W.⁷⁸⁹¹⁰³,Reekie Tristan A.¹²³,Munoz Lenka¹¹²⁵³,Wong Erick C. N.⁶¹²²⁵³,Ittner Lars M.⁷⁸⁹¹⁰³,Kassiou Michael¹²³

Affiliation:

1. School of Chemistry

2. The University of Sydney

3. Australia

4. Faculty of Health Sciences

5. NSW 2006

6. School of Medical Sciences (Pharmacology)

7. Dementia Research Unit

8. School of Medical Sciences

9. University of New South Wales

10. NSW 2052

11. School of Medical Sciences (Pathology) and Charles Perkins Centre

12. Bosch Institute

Abstract

The 18 kDa translocator protein (TSPO) is a target for development of diagnostic imaging agents for glioblastoma and neuroinflammation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00523C

Reference46 articles.

1. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

2. Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis

3. Involvement of Peripheral-Type Benzodiazepine Receptors in the Intracellular Transport of Heme and Porphyrins1

4. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

5. Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis

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3. Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism;European Journal of Nuclear Medicine and Molecular Imaging;2021-11-16

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