T- and B-cell immunosuppressive activity of novel α-santonin analogs with humoral and cellular immune response in Balb/c mice-Reference-Cited by-同舟云学术

T- and B-cell immunosuppressive activity of novel α-santonin analogs with humoral and cellular immune response in Balb/c mice

Published:2017 Issue:1 Volume:8 Page:211-219
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Dangroo Nisar A.¹²³,Singh Jasvinder⁴⁵²³⁶,Gupta Nidhi¹²³,Singh Shashank⁴⁵²³⁶,Kaul Anapurna⁴⁵²³,Khuroo Mohmmed A.⁷⁸³,Sangwan Payare L.¹²³⁶⁹

Affiliation:

1. Bioorganic Chemistry Division

2. Jammu-180001

3. India

4. Cancer Pharmacology Division

5. CSIR-Indian Institute of Integrative Medicine

6. Academy of Scientific and Innovative Research (AcSIR)

7. University of Kashmir

8. Srinagar

9. CSIR-IIIM Campus

Abstract

Herein we report the synthesis of α-santonin analogs, and identification of potent immunosuppressant molecules. In vivo investigation on BALB/c mice revealed that compound 4e suppresses both humoral and cellular immunity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00527F

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