Synthesis and cytotoxic evaluation of several oleanolic acid–uracil/thymine conjugates-Reference-Cited by-同舟云学术

Synthesis and cytotoxic evaluation of several oleanolic acid–uracil/thymine conjugates

Published:2016 Issue:5 Volume:7 Page:972-981
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Cheng Ke-Guang¹²³⁴,Su Chun-Hua¹²³⁴,Huang Jia-Yan¹²³⁴,Wang Heng-Shan¹²³⁴,Liu Jun⁵⁶⁷⁴,Zheng Yuan-Ting⁸⁹¹⁰¹¹¹²,Chen Zhen-Feng¹²³⁴

Affiliation:

1. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources

2. School of Chemistry and Pharmacy of Guangxi Normal University

3. Guilin 541004

4. PR China

5. Jiangsu Key Laboratory of Drug Screening

6. China Pharmaceutical University

7. Nanjing 210009

8. Department of Clinical Pharmacy

9. School of Pharmacy

10. Fudan University

11. Shanghai 201203

12. China

Abstract

Some IC₅₀ values of sixteen synthesized oleanolic acid–uracil/thymine hybrids were under 0.1 μM against tested cells (Hep-G2, A549, BGC-823, MCF-7 and PC-3).

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00061D

Reference32 articles.

1. Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid–AZT conjugates

2. Hybrid Molecules Incorporating Natural Products: Applications in Cancer Therapy, Neurodegenerative Disorders and Beyond

3. Oleanolic acid

4. Methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL), a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MDA-MB-231 breast cancer cells

5. Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: Preclinical and clinical evidence

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. New phorbol ester derivatives as potent anti-HIV agents;Bioorganic & Medicinal Chemistry Letters;2021-10

2. Structure and Activity of Pentacyclic Triterpenes Codrugs. A Review;Mini-Reviews in Medicinal Chemistry;2021-01-05

3. Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives;Future Medicinal Chemistry;2020-10

4. β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets;European Journal of Medicinal Chemistry;2020-09

5. Synthesis of oleanolic acid analogues targeting PDGF receptor inhibitors and their antitumor biological activities;Journal of Asian Natural Products Research;2020-02-26