Polyamine-based small molecule epigenetic modulators-Reference-Cited by-同舟云学术

Polyamine-based small molecule epigenetic modulators

Published:2012 Issue:1 Volume:3 Page:14-21
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sharma Shiv K.¹²³⁴,Hazeldine Stuart¹²³⁴,Crowley Michael L.¹²³⁴,Hanson Allison¹²³⁴,Beattie Ross¹²³⁴,Varghese Sheeba¹²³⁴,Senanayake Thulani M. D.¹²³⁴,Hirata Aiko¹²³⁴,Hirata Fusao¹²³⁴,Huang Yi⁵⁶⁷⁸⁴,Wu Yu⁵⁶⁷⁸⁴,Steinbergs Nora⁵⁶⁷⁸⁴,Murray-Stewart Tracey⁵⁶⁷⁸⁴,Bytheway Ian⁹¹⁰¹¹,Casero Robert A.⁵⁶⁷⁸⁴,Woster Patrick M.¹²¹³¹⁴⁴

Affiliation:

1. Department of Pharmaceutical Sciences

2. Wayne State University

3. Detroit

4. USA

5. Department of Oncology

6. The Sidney Kimmel Comprehensive Cancer Center

7. Johns Hopkins University

8. Baltimore

9. Progen Pharmaceuticals, Ltd.

10. Darra

11. Australia

12. Department of Pharmaceutical and Biomedical Sciences

13. Medical University of South Carolina

14. Charleston

Abstract

Multiple series of HDAC and LSD1 inhibitors have been developed that increase histone lysine methylation and promote the re-expression of aberrantly silenced genes that are important in human cancer..

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2012/MD/C1MD00220A

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