Identification and analysis of the cleavage site in a signal peptide using SMOTE, dagging, and feature selection methods

Author:

Wang ShaoPeng1234ORCID,Wang Deling56789,Li JiaRui1234,Huang Tao101112134ORCID,Cai Yu-Dong1234ORCID

Affiliation:

1. School of Life Sciences

2. Shanghai University

3. Shanghai 200444

4. People's Republic of China

5. Department of Medical Imaging

6. Sun Yat-sen University Cancer Center

7. State Key Laboratory of Oncology in South China

8. Collaborative Innovation Center for Cancer Medicine

9. Guangzhou

10. Institute of Health Sciences

11. Shanghai Institutes for Biological Sciences

12. Chinese Academy of Sciences

13. Shanghai 200031

Abstract

Several machine learning algorithms were adopted to investigate cleavage sites in a signal peptide. An optimal dagging based classifier was constructed and 870 important features were deemed to be important for this classifier.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

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