Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-β peptides

Author:

Kinoshita Misaki1234,Kakimoto Erina1234,Terakawa Mayu S.12345,Lin Yuxi1234,Ikenoue Tatsuya12346,So Masatomo1234,Sugiki Toshihiko1234,Ramamoorthy Ayyalusamy678910ORCID,Goto Yuji1234,Lee Young-Ho1234ORCID

Affiliation:

1. Institute for Protein Research

2. Osaka University

3. Suita

4. Japan

5. Department of Biochemistry

6. Department of Chemistry

7. University of Michigan

8. Ann Arbor

9. USA

10. Biophysics Program

Abstract

We herein report the mechanism of amyloid formation of amyloid-β (Aβ) peptides on small (SUV) and large unilamellar vesicles (LUVs), which consist of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipids.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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