Complete switch from α-2,3- to α-2,6-regioselectivity in Pasteurella dagmatis β-d-galactoside sialyltransferase by active-site redesign-Reference-Cited by-同舟云学术

Complete switch from α-2,3- to α-2,6-regioselectivity in Pasteurella dagmatis β-d-galactoside sialyltransferase by active-site redesign

Published:2015 Issue:15 Volume:51 Page:3083-3086
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Schmölzer Katharina¹²³,Czabany Tibor⁴⁵²³,Luley-Goedl Christiane¹²³,Pavkov-Keller Tea¹²³,Ribitsch Doris¹²³,Schwab Helmut⁶⁵²³,Gruber Karl⁷⁸²³,Weber Hansjörg⁹⁵²³,Nidetzky Bernd¹²³⁴⁵

Affiliation:

1. Austrian Centre of Industrial Biotechnology

2. 8010 Graz

3. Austria

4. Institute of Biotechnology and Biochemical Engineering

5. Graz University of Technology

6. Institute of Molecular Biotechnology

7. Institute of Molecular Biosciences

8. University of Graz

9. Institute of Organic Chemistry

Abstract

Incorporation of Pro7His and Met117Ala substitutions resulted in a completely regioselective and highly efficient α-2,6-sialyltransferase.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC09772F

Reference38 articles.

1. Sialic acids in human health and disease

2. Sialic acids as regulators of molecular and cellular interactions

3. Human milk oligosaccharides: Every baby needs a sugar mama

4. Oligosaccharides in Human Milk: Structural, Functional, and Metabolic Aspects

5. The role of oligosaccharides from human milk and other sources in prevention of pathogen adhesion

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