Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy-Reference-Cited by-同舟云学术

Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy

Published:2019 Issue:23 Volume:17 Page:5698-5702
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zuo Chao¹²³⁴⁵,Yan Bing-Jia⁶⁷⁸⁹,Zhu Han-Ying¹²³⁴⁵,Shi Wei-Wei⁶⁷⁸⁹,Xi Tong-Kuai¹²³⁴⁵,Shi Jing⁶¹⁰¹¹⁹,Fang Ge-Min¹²³⁴⁵^ORCID

Affiliation:

1. School of Life Science

2. Institute of Health Science and Technology

3. Institutes of Physical Science and Information Technology

4. Anhui University

5. Hefei 230601

6. Department of Chemistry

7. Tsinghua University

8. Beijing 100084

9. PR China

10. University of Science and Technology of China

11. Hefei 230026

Abstract

A simple-to-operate and highly efficient strategy for the epimerization-free synthesis of C-terminal Cys-containing peptide acids, which avoids the use of derivatization reagents for resin modification, is developed.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01114E

Reference34 articles.

1. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

2. The Chemistry and Biological Activities of Peptides from Amphibian Skin Secretions

3. Chemical Modification of Conotoxins to Improve Stability and Activity

4. Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics

5. An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide

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