Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates-Reference-Cited by-同舟云学术

Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates

Published:2020 Issue:2 Volume:11 Page:467-473
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kawahara Brian¹²³⁴,Gao Lucy⁵⁶⁷⁸⁴,Cohn Whitaker⁵⁶⁷⁸⁴,Whitelegge Julian P.⁵⁶⁷⁸⁴,Sen Suvajit⁹¹⁰⁷⁸⁴,Janzen Carla⁹¹⁰⁷⁸⁴,Mascharak Pradip K.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of California

3. Santa Cruz

4. USA

5. Pasarow Mass Spectrometry Laboratory

6. Jane and Terry Semel Institute for Neuroscience and Human Behavior

7. University of California at Los Angeles

8. Los Angeles

9. Department of Obstetrics and Gynecology

10. David Geffen School of Medicine

Abstract

Antibodies conjugated to a photoactive transition metal carbonyl complex afford antigen-directed delivery of cytotoxic carbon monoxide to ovarian cancer cells.

Funder

National Science Foundation

Cancer Research Coordinating Committee

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC03166A

Reference31 articles.

1. Biological signaling by carbon monoxide and carbon monoxide-releasing molecules