Regulating tumor glycometabolism and the immune microenvironment by inhibiting lactate dehydrogenase with platinum(<scp>iv</scp>) complexes-Reference-Cited by-同舟云学术

Regulating tumor glycometabolism and the immune microenvironment by inhibiting lactate dehydrogenase with platinum(iv) complexes

Published:2023 Issue:31 Volume:14 Page:8327-8337
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Jin Suxing¹²^ORCID,Yin Enmao¹,Feng Chenyao¹,Sun Yuewen¹,Yang Tao³⁴,Yuan Hao³,Guo Zijian³⁴^ORCID,Wang Xiaoyong¹^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China

2. School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P. R. China

3. State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China

4. Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, P. R. China

Abstract

Diclofenac-tethered Pt complexes restrain lactate formation from pyruvate and its transport by repressing LDHs and MCTs, polarize macrophages from M2 to M1 types, and impede angiogenesis, thus potentiating the anticancer activity and immune response.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01874A

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1. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

2. Hallmarks of Cancer: The Next Generation