Synthesis and evaluation of tirbanibulin derivatives: a detailed exploration of the structure–activity relationship for anticancer activity-Reference-Cited by-同舟云学术

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Synthesis and evaluation of tirbanibulin derivatives: a detailed exploration of the structure–activity relationship for anticancer activity

Published:2023 Issue:50 Volume:13 Page:35583-35591
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Park Jaebeom¹²,Kang Minji¹³,Lim Ahyoung¹,Cho Kyung-Jin¹,Chae Chong Hak¹,Koh Byumseok¹³^ORCID,Jeon Hongjun¹³^ORCID

Affiliation:

1. Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea

2. College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea

3. Medicinal Chemistry & Pharmacology, University of Science & Technology, Daejeon 34113, Republic of Korea

Abstract

The structure–activity relationship of the synthesized tirbanibulin derivatives was explored; para fluorination on the benzylamine part yielded promising outcomes in potency and pharmacokinetics.

Funder

Korea Research Institute of Chemical Technology

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA06790D

Reference38 articles.

1. Future prospects for mitosis-targeted antitumor therapies

2. Anti-mitotic therapies in cancer

3. Perturbing mitosis for anti‐cancer therapy: is cell death the only answer?

4. Targeting Mitosis in Cancer: Emerging Strategies

5. Mitosis-targeted anti-cancer therapies: where they stand

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