Insights into the function of trans-acyl transferase polyketide synthases from the SAXS structure of a complete module
Author:
Affiliation:
1. Molecular and Structural Enzymology Group
2. Université de Lorraine
3. Vandœuvre-Lès-Nancy, France
Abstract
Combined analysis by SAXS, NMR and homology modeling reveals the structure of an apo module from a trans-acyltransferase polyketide synthase.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/SC/C3SC53511H
Reference73 articles.
1. The type I fatty acid and polyketide synthases: a tale of two megasynthases
2. The structural role of the carrier protein – active controller or passive carrier
3. Chapter 6 The DEBS Paradigm for Type I Modular Polyketide Synthases and Beyond
4. Biosynthesis of polyketides by trans-AT polyketide synthases
5. Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
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