New insights into controlling radical migration pathways in heme enzymes gained from the study of a dye-decolorising peroxidase-Reference-Cited by-同舟云学术

New insights into controlling radical migration pathways in heme enzymes gained from the study of a dye-decolorising peroxidase

Published:2023 Issue:44 Volume:14 Page:12518-12534
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Lučić Marina¹^ORCID,Wilson Michael T.¹,Pullin Jacob¹^ORCID,Hough Michael A.¹²^ORCID,Svistunenko Dimitri A.¹^ORCID,Worrall Jonathan A. R.¹^ORCID

Affiliation:

1. School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK

2. Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK

Abstract

We show that radical migration in a heme peroxidase can be controlled and directed to a rationally designed site through simply removing an oxygen atom form the protein structure.

Funder

Royal Society of Chemistry

Diamond Light Source

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC04453J

Reference84 articles.

1. Variable-Temperature Spectroelectrochemical Study of Horseradish Peroxidase

2. The Redox Properties of Ascorbate Peroxidase

3. Heme Enzyme Structure and Function

4. Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins

5. Reduction Potentials of P450 Compounds I and II: Insight into the Thermodynamics of C–H Bond Activation

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