Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B-Reference-Cited by-同舟云学术

Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B

Published:2021 Issue:6 Volume:11 Page:3216-3220
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mu Xu-Yang¹²³⁴,Wang Zhi-Jia¹²³⁴,Feng Bo¹²³⁴,Xu Lei⁵⁶⁷⁸⁴,Gao Li-Xin⁵⁶⁷⁸⁴,Satheeshkumar Rajendran¹²³⁴⁹^ORCID,Li Jia⁵⁶⁷⁸⁴,Zhou Yu-Bo⁵⁶⁷⁸⁴,Wang Wen-Long¹²³⁴^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Jiangnan University

3. Wuxi

4. China

5. State Key Laboratory of Drug Research

6. Shanghai Institute of Materia Medica

7. Chinese Academy of Sciences

8. Shanghai

9. Departamento de Química Orgánica

Abstract

A series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived “green” solvent γ-valerolactone and evaluated for their inhibitory activities against PTP1B, compound6adisplayed an IC₅₀value of 8.04 ± 0.71 μM with 4.34-fold preference over TCPTP.

Funder

Natural Science Foundation of Jiangsu Province

National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA09247A

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