m-Cresol affects the lipid bilayer in membrane models and living neurons-Reference-Cited by-同舟云学术

m-Cresol affects the lipid bilayer in membrane models and living neurons

Published:2016 Issue:107 Volume:6 Page:105699-105712
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Paiva T. O.¹²³⁴⁵,Bastos A. E. P.¹²³⁴⁵,Marquês J. T.¹²³⁴⁵,Viana A. S.¹²³⁴⁵,Lima P. A.⁶⁷⁸⁵,de Almeida R. F. M.¹²³⁴⁵

Affiliation:

1. Centro de Química e Bioquímica

2. DQB

3. Faculdade de Ciências da Universidade de Lisboa

4. 1749-016 Lisboa

5. Portugal

6. NOVA Medical School

7. Faculdade de Ciências Médicas da Universidade Nova de Lisboa

8. 1169-056 Lisboa

Abstract

A preferential interaction of m-cresol with high dipole-potential cholesterol/sphingomyelin-enriched lipid domains jeopardizes membrane integrity, explaining the toxicity of m-cresol-containing insulin formulations.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA20337J

Reference52 articles.

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2. Cresol Isomers: Comparison of Toxic Potency in Rat Liver Slices

3. p-Cresol Affects Reactive Oxygen Species Generation, Cell Cycle Arrest, Cytotoxicity and Inflammation/Atherosclerosis-Related Modulators Production in Endothelial Cells and Mononuclear Cells

4. Carriage of Staphylococcus aureus and Inflamed Infusion Sites With Insulin-Pump Therapy

5. Preservatives in Insulin Preparations Impair Leukocyte Function: In vitro study

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