Transformation of theranostic alginate-based microbubbles from raspberry-like to core–shell-like microbubbles and in vitro studies

Author:

Bai Meng-Yi12ORCID,Chen Tsai-Hsuan1,Wang Yu-Chi3,Lai Yu-Ju3

Affiliation:

1. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, No. 43, Keelung Rd, Sec. 4, Da'an Dist., Taipei City 10607, Taiwan

2. Adjunct Appointment to the Departmnet of Biomedical Engineering, National Defense Medical Centre, Taipei 11490, Taiwan

3. Department of Obstetric and Gynecology, Tri-Service General Hospital, National Defense Medical Centre, Taiwan

Abstract

In this study alginate-based microbubbles with a raspberry-like or core–shell-like morphology and with an average particle size of 553.6 ± 69.6 μm were synthesized; this was done through a transformation of the structure with applying a 40 kHz ultrasonication.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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