Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin-Reference-Cited by-同舟云学术

Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

Published:2014 Issue:16 Volume:12 Page:2568-2575
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cheng Mu¹²³⁴,Ziora Zyta M.¹²³⁴,Hansford Karl A.¹²³⁴,Blaskovich Mark A.¹²³⁴,Butler Mark S.¹²³⁴,Cooper Matthew A.¹²³⁴

Affiliation:

1. Division of Chemistry and Structural Biology

2. Institute for Molecular Bioscience

3. The University of Queensland

4. Brisbane, Australia

Abstract

Dalbavancin, a semi-synthetic glycopeptide with enhanced antibiotic activity compared to vancomycin and teicoplanin, dimerises strongly in an anti-cooperative manner with ligand binding.

Funder

National Health and Medical Research Council

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42428F

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