Elucidation of the structural stability and dynamics of heterogeneous intermediate ensembles in unfolding pathway of the N-terminal domain of TDP-43-Reference-Cited by-同舟云学术

Elucidation of the structural stability and dynamics of heterogeneous intermediate ensembles in unfolding pathway of the N-terminal domain of TDP-43

Published:2018 Issue:35 Volume:8 Page:19835-19845
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Prakash Amresh¹²³⁴^ORCID,Kumar Vijay⁵⁶⁷⁴^ORCID,Meena Naveen Kumar¹²³⁴,Lynn Andrew M.¹²³⁴

Affiliation:

1. School of Computational & Integrative Sciences

2. Jawaharlal Nehru University

3. New Delhi-110067

4. India

5. Centre for Interdisciplinary Research in Basic Sciences

6. Jamia Millia Islamia

7. New Delhi-110025

Abstract

The N-terminal domain of the RNA binding protein TDP-43 (NTD) is essential to both physiology and proteinopathy; however, elucidation of its folding/unfolding still remains a major quest.

Funder

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA03368D

Reference68 articles.

1. Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

2. Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning

3. Delineating the relationship between amyotrophic lateral sclerosis and frontotemporal dementia: Sequence and structure-based predictions

4. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

5. Rethinking ALS: The FUS about TDP-43

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