Glycoconjugate synthesis using chemoselective ligation

Author:

Cheng Shuihong12345,Wantuch Paeton L.678910,Kizer Megan E.1112131415ORCID,Middleton Dustin R.678910,Wang Ruitong1112131415,DiBello Mikaela1112131415,Li Mingli12345,Wang Xing1112131415ORCID,Li Xuebing12345ORCID,Ramachandiran Vasanthi16171815,Avci Fikri Y.678910,Zhang Fuming1112131415,Zhang Xing1112131415,Linhardt Robert J.1112131415ORCID

Affiliation:

1. CAS Key Laboratory of Pathogenic Microbiology and Immunology

2. Institute of Microbiology

3. Chinese Academy of Sciences

4. Beijing 100101

5. China

6. Department of Biochemistry and Molecular Biology

7. Center for Molecular Medicine

8. and Complex Carbohydrate Research Center

9. University of Georgia

10. Athens

11. Department of Chemistry and Chemical Biology

12. Center for Biotechnology and Interdisciplinary Studies

13. Rensselaer Polytechnic Institute

14. Troy

15. USA

16. NIH Tetramer Core Facility

17. Emory University

18. Atlanta

Abstract

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker.

Funder

National Natural Science Foundation of China

State Key Laboratory of Microbial Resources

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference32 articles.

1. Essentials of Glycobiology , ed. A. Varki , R. D. Cummings , J. D. Esko , P. Stanley , G. W. Hart , M. Aebi , A. G. Darvill , T. Kinoshita , N. H. Packer , J. H. Prestegard , R. L. Schnaar and P. H. Seeberger , Cold Spring Harbor Press , NY , 2017

2. Carbohydrate Based Vaccines

3. J. Hütter and B.Lepenies , in Carbohydrate-Based Vaccines: Methods and Protocols , ed. B. Lepenies , Springer New York , New York, NY , 2015 , pp. 1–10

4. How Bacterial Carbohydrates Influence the Adaptive Immune System

5. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS

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