Structural and mechanistic insight into DNA bending by antitumour calicheamicins-Reference-Cited by-同舟云学术

Structural and mechanistic insight into DNA bending by antitumour calicheamicins

Published:2021 Issue:30 Volume:19 Page:6707-6717
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mills Alberto¹²³⁴^ORCID,Gago Federico¹²³⁴^ORCID

Affiliation:

1. Departamento de Ciencias Biomédicas y “Unidad Asociada IQM-CSIC”

2. Universidad de Alcalá

3. E-28805 Alcalá de Henares

4. Spain

Abstract

Atomistic molecular dynamics simulations shed structural light on the curvature inflicted on DNA upon binding of calicheamicin ε to high-affinity and low-affinity target sites.

Funder

Universidad de Alcalá

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01077H

Reference60 articles.

1. Calicheamicins: discovery, structure, chemistry, and interaction with DNA

2. Antibody-targeted chemotherapy with immunoconjugates of calicheamicin

3. Antibody-Drug Conjugates of Calicheamicin Derivative: Gemtuzumab Ozogamicin and Inotuzumab Ozogamicin

4. Comparing cure rates for gemtuzumab ozogamicin plus standard chemotherapy vs standard chemotherapy alone in acute myeloid leukemia patients

5. Preclinical and clinical development of inotuzumab-ozogamicin in hematological malignancies

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