Efficient stereoselective synthesis of aryl lactones using engineered ketoreductase <i>Ch</i>KRED20 from <i>Chryseobacterium</i> sp. CA49-Reference-Cited by-同舟云学术

Efficient stereoselective synthesis of aryl lactones using engineered ketoreductase ChKRED20 from Chryseobacterium sp. CA49

Published:2024 Issue:6 Volume:11 Page:1804-1810
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Shi Mingliang¹,Lin Rude¹,Yu Yuan¹,Yao Yao¹,Fan Xinyue¹,Li Kun¹^ORCID,Wu Zhongliu²^ORCID,Yu Xiaoqi¹^ORCID,Liu Yan²,Wang Na¹^ORCID

Affiliation:

1. Key Laboratory of Green Chemistry Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China

2. CAS Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610064, PR China

Abstract

WT ChKRED20 which exhibits no activity towards γ,δ-keto esters was redesigned for reducing bulky keto esters to the corresponding lactones.

Funder

National Basic Research Program of China

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO02076B

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5. Preparation of Enantioenriched γ-Substituted Lactones via Asymmetric Transfer Hydrogenation of β-Azidocyclopropane Carboxylates Using the Ru-TsDPEN Complex

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