Ultrasensitive detection of SARS-CoV-2 spike protein by graphene field-effect transistors-Reference-Cited by-同舟云学术

Ultrasensitive detection of SARS-CoV-2 spike protein by graphene field-effect transistors

Published:2023 Issue:3 Volume:15 Page:1076-1085
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Silvestri Alessandro¹^ORCID,Zayas-Arrabal Julian¹^ORCID,Vera-Hidalgo Mariano¹,Di Silvio Desire¹,Wetzl Cecilia¹²^ORCID,Martinez-Moro Marta¹,Zurutuza Amaia³,Torres Elias³,Centeno Alba³,Maestre Arantxa³,Gómez Juan Manuel³,Arrastua María³,Elicegui Marta³,Ontoso Nerea³,Prato Maurizio¹⁴⁵^ORCID,Coluzza Ivan⁶⁵,Criado Alejandro¹⁷^ORCID

Affiliation:

1. Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain

2. University of the Basque Country UPV-EHU, 20018 Donostia-San Sebastián, Spain

3. Graphenea Semiconductor SLU., Paseo Mikeletegi 83, 20009 San Sebastián, Spain

4. Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 3412 7 Trieste, Italy

5. Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain

6. BCMaterials, Basque Center for Materials, Applications and Nanostructures, Bld. Martina Casiano, UPV/EHU Science Park, Barrio Sarriena s/n, 48940 Leioa, Spain

7. Universidade da Coruña, CICA – Centro Interdisciplinar de Química e Bioloxía, Rúa as Carballeiras, 15071 A Coruña, Spain

Abstract

By finely controlling the graphene functionalisation, by tuning the Debye length, and by deeply characterising the ACE2-spike protein interactions, we have been able to detect SARS-CoV-2 spike protein with an extremely low limit of detection.

Funder

AXA Research Fund

Ministerio de Ciencia e Innovación

Xunta de Galicia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D2NR05103F

Reference33 articles.

1. COVID-19 Antibody Tests and Their Limitations