A glutamic acid-based traceless linker to address challenging chemical protein syntheses-Reference-Cited by-同舟云学术

A glutamic acid-based traceless linker to address challenging chemical protein syntheses

Published:2021 Issue:40 Volume:19 Page:8821-8829
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Giesler Riley J.¹,Spaltenstein Paul¹^ORCID,Jacobsen Michael T.²,Xu Weiliang¹,Maqueda Mercedes³,Kay Michael S.¹^ORCID

Affiliation:

1. Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Room 4100, Salt Lake City, Utah 84112-5650, USA

2. Department of Pediatrics, Division of Diabetes and Endocrinology, Stanford University, Palo Alto, CA 94304, USA

3. Departamento de Microbiología, Universidad de Granada, Avda. Fuentenueva, s/n, 18071 Granada, Spain

Abstract

Poor peptide solubility is a challenge in chemical protein synthesis. The new Fmoc-(l)-Glu(AlHx)-OH tool was used to efficiently synthesize the challenging bacteriocin AS-48.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01611C

Reference73 articles.

1. Synthesis of Proteins by Native Chemical Ligation

2. Synthesis of Peptides and Proteins without Cysteine Residues by Native Chemical Ligation Combined with Desulfurization

3. Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

4. Solid-Phase Peptide Synthesis. III. An Improved Synthesis of Bradykinin*

5. Chemical Protein Synthesis with the α-Ketoacid–Hydroxylamine Ligation

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