Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody-Reference-Cited by-同舟云学术

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Published:2020 Issue:96 Volume:56 Page:15137-15140
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Macías-León Javier¹²³⁴^ORCID,Bermejo Iris A.⁵⁶⁷⁴^ORCID,Asín Alicia⁵⁶⁷⁴,García-García Ana¹²³⁴,Compañón Ismael⁵⁶⁷⁴,Jiménez-Moreno Ester⁵⁶⁷⁴^ORCID,Coelho Helena⁸⁹¹⁰¹¹¹²,Mangini Vincenzo¹³¹⁴¹⁵¹⁶^ORCID,Albuquerque Inês S.¹⁷¹⁸¹⁹²⁰²¹^ORCID,Marcelo Filipa⁸⁹¹⁰¹¹¹²^ORCID,Asensio Juan L.²²²³²⁴⁴,Bernardes Gonçalo J. L.¹⁷¹⁸¹⁹²⁰²¹^ORCID,Joshi Hiren J.²⁵²⁶²⁷²⁸²⁹^ORCID,Fiammengo Roberto¹³¹⁴¹⁵¹⁶^ORCID,Blixt Ola²⁵²⁶²⁷²⁸²⁹,Hurtado-Guerrero Ramón¹²³⁴²⁵^ORCID,Corzana Francisco⁵⁶⁷⁴^ORCID

Affiliation:

1. Institute of Biocomputation and Physics of Complex Systems (BIFI)

2. University of Zaragoza

3. Zaragoza

4. Spain

5. Department of Chemistry

6. University of La Rioja

7. Logroño

8. UCIBIO

9. REQUIMTE

10. Departamento de Química

11. Faculdade de Ciências e Tecnologia

12. Universidade NOVA de Lisboa

13. Center for Biomolecular Nanotechnologies@UniLe

14. Istituto Italiano di Tecnologia (IIT)

15. 73010 Arnesano

16. Italy

17. Instituto de Medicina Molecular

18. Faculdade de Medicina

19. Universidade de Lisboa

20. Lisboa

21. Portugal

22. Instituto de Química Organica General

23. IQOG-CSIC

24. 28006 Madrid

25. Copenhagen Center for Glycomics

26. Department of Cellular and Molecular Medicine

27. University of Copenhagen

28. Copenhagen

29. Denmark

Abstract

The molecular basis of an anti-MUC1 antibody that recognizes the entire GalNAc unit as a primary epitope is disclosed.

Funder

Agencia Estatal de Investigación

Ministero dell’Istruzione, dell’Università e della Ricerca

Royal Society

Fundação para a Ciência e a Tecnologia

Fundación Científica Asociación Española Contra el Cáncer

Danmarks Grundforskningsfond

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC06349E

Reference24 articles.

1. Cancer-associated mucins: role in immune modulation and metastasis

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5. Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are associated with a better prognosis

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