Impact of β-perfluoroalkyl substitution of proline on the proteolytic stability of its peptide derivatives-Reference-Cited by-同舟云学术

Impact of β-perfluoroalkyl substitution of proline on the proteolytic stability of its peptide derivatives

Published:2022 Issue:47 Volume:20 Page:9337-9350
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Chernykh Anton V.¹²,Aloshyn Danylo³,Kuchkovska Yuliya O.¹,Daniliuc Constantin G.⁴^ORCID,Tolmachova Nataliya A.¹,Kondratov Ivan S.¹⁵,Zozulya Sergey³,Grygorenko Oleksandr O.¹²^ORCID,Haufe Günter⁴⁶^ORCID

Affiliation:

1. Enamine Ltd., Chervonotkatska Street 78, Kyïv 02094, Ukraine

2. Taras Shevchenko National University of Kyïv, Volodymyrska Street 60, Kyïv 01601, Ukraine

3. Bienta/Enamine Ltd., Chervonotkatska Street 78, Kyïv 02094, Ukraine

4. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany

5. V.P. Kukhar Institute of Bioorganic Chemistry & Petrochemistry, National Academy of Sciences of, Ukraine, Murmanska Street 1, Kyïv 02660, Ukraine

6. Cells-in-Motion Cluster of Excellence, Universität Münster, Waldeyerstraße 15, 48149 Münster, Germany

Abstract

The synthesis of all enantiopure N-Boc-protected β-CF3- and β-C2F5-prolines and the stability of their model dipeptide derivatives towards proteolytic degradation are reported.

Funder

Deutsche Forschungsgemeinschaft

Enamine

Ministry of Education and Science of Ukraine

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01430K

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