Design, synthesis and biological evaluation of phenanthridine amide and 1,2,3-triazole analogues against Mycobacterium tuberculosis

Author:

Nandikolla Adinarayana1ORCID,Khetmalis Yogesh Mahadu1,Venkata Siva Kumar Boddupalli1,Chandu Ala2,Karan Kumar Banoth2ORCID,Shetye Gauri3,Ma Rui3,Murugesan Sankaranarayanan2ORCID,Franzblau Scott G.3,Chandra Sekhar Kondapalli Venkata Gowri1ORCID

Affiliation:

1. Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad – 500078, Telangana, India

2. Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani-333031, Rajasthan, India

3. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA

Abstract

Amongst the Phenanthridine amides and triazoles reported in this work, PA-01 and PT-09 emerged as the most active anti-tubercular agents against Mtb H37Rv strain in MABA and LORA assays.

Funder

Council of Scientific and Industrial Research, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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