Design, synthesis and biological evaluation of phenanthridine amide and 1,2,3-triazole analogues against <i>Mycobacterium tuberculosis</i>-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of phenanthridine amide and 1,2,3-triazole analogues against Mycobacterium tuberculosis

Published:2023 Issue:8 Volume:14 Page:1549-1561
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Nandikolla Adinarayana¹^ORCID,Khetmalis Yogesh Mahadu¹,Venkata Siva Kumar Boddupalli¹,Chandu Ala²,Karan Kumar Banoth²^ORCID,Shetye Gauri³,Ma Rui³,Murugesan Sankaranarayanan²^ORCID,Franzblau Scott G.³,Chandra Sekhar Kondapalli Venkata Gowri¹^ORCID

Affiliation:

1. Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad – 500078, Telangana, India

2. Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani-333031, Rajasthan, India

3. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA

Abstract

Amongst the Phenanthridine amides and triazoles reported in this work, PA-01 and PT-09 emerged as the most active anti-tubercular agents against Mtb H37Rv strain in MABA and LORA assays.

Funder

Council of Scientific and Industrial Research, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00115F

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