Hybridization of an Aβ-specific antibody fragment with aminopyrazole-based β-sheet ligands displays striking enhancement of target affinity
Author:
Affiliation:
1. Institute for Organic Chemistry
2. University of Duisburg-Essen
3. 45117 Essen
4. Germany
5. Department of Neuropathology
6. Heinrich Heine University
7. 40225 Düsseldorf
Abstract
A His-tagged antibody is combined with an NTA-β-sheet breaker and displays a striking increase in Aβ affinity.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02411G
Reference20 articles.
1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2. The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
3. Alzheimer disease
4. Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease
5. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Unnatural Amino Acid: 4-Aminopyrazolonyl Amino Acid Comprising Tri-Peptides Forms Organogel With Co-Solvent (EtOAc:Hexane);Frontiers in Chemistry;2022-05-05
2. Reactivities of cyclam derivatives with metal–amyloid-β;Inorganic Chemistry Frontiers;2020
3. Synthesis and Conformational Analysis of Aminopyrazolonyl Amino Acid (APA)/Peptides;European Journal of Organic Chemistry;2019-01-23
4. Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology;Molecular Neurobiology;2018-07-12
5. Modulators of Amyloid β-Protein (Aβ) Self-Assembly;Developing Therapeutics for Alzheimer's Disease;2016
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3