Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding-Reference-Cited by-同舟云学术

Enhancing the enthalpic contribution of hydrogen bonds by solvent shielding

Published:2020 Issue:4 Volume:1 Page:281-287
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Cramer Jonathan¹²³⁴^ORCID,Jiang Xiaohua¹²³⁴,Schönemann Wojciech¹²³⁴,Silbermann Marleen¹²³⁴,Zihlmann Pascal¹²³⁴,Siegrist Stefan¹²³⁴,Fiege Brigitte¹²³⁴,Jakob Roman Peter⁵²³⁴^ORCID,Rabbani Said¹²³⁴,Maier Timm⁵²³⁴^ORCID,Ernst Beat¹²³⁴^ORCID

Affiliation:

1. Institute of Molecular Pharmacy

2. University of Basel

3. 4056 Basel

4. Switzerland

5. Institute of Structural Biology

Abstract

Altering local dielectric properties induced by solvent shielding, enhances polar interactions and leads to enthalpically driven recognition of polar substrates.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CB/D0CB00108B

Reference40 articles.

1. What Can We Learn from Molecular Recognition in Protein–Ligand Complexes for the Design of New Drugs?

2. Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

3. G. M. Keserü and D. C.Swinney , Thermodynamics and Kinetics of Drug Binding , Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim, Germany , 2015