A fluorescent method based on magnetic nanoparticles for detection of CGG trinucleotide repeat genes
Author:
Affiliation:
1. Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules
2. College of Chemistry and Chemical Engineering
3. Hubei University
4. Youyi Road 368
5. Wuchang
Abstract
A novel fluorescent sensor based on magnetic nanoparticles as the separator and short report DNA was designed and prepared for the detection of d(CGG)ntrinucleotide repeats. The method exhibited high selectivity and sensitivity, and excellent linear correlation from 100 pM to 150 nM, which is useful for the early diagnosis of neurodegenerative diseases.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C8NJ04686G
Reference28 articles.
1. Expandable DNA repeats and human disease
2. Epigenetic modifications in trinucleotide repeat diseases
3. DNA repair in the trinucleotide repeat disorders
4. Disease-associated repeat instability and mismatch repair
5. Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox
Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Droplet magnetic-controlled microfluidic chip integrated nucleic acid extraction and amplification for the detection of pathogens and tumor mutation sites;Analytica Chimica Acta;2023-08
2. Application of magnetic nanoparticles in nucleic acid detection;Journal of Nanobiotechnology;2020-04-21
3. A novel solution-gated graphene transistor biosensor for ultrasensitive detection of trinucleotide repeats;The Analyst;2020
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3