Cinnamaldehyde causes developmental neurotoxicity in zebrafish <i>via</i> the oxidative stress pathway that is rescued by astaxanthin-Reference-Cited by-同舟云学术

Cinnamaldehyde causes developmental neurotoxicity in zebrafish via the oxidative stress pathway that is rescued by astaxanthin

Published:2022 Issue:24 Volume:13 Page:13028-13039
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Chang Kaihui¹²^ORCID,Zeng Nan³⁴,Ding Yonghe²,Zhao Xiangzhong²,Gao Chengwen²,Li Yafang¹,Wang Haoxu¹,Liu Xiaoyu¹,Niu Yujuan²,Sun Yuanchao²,Li Teng²,Shi Yongyong²,Wu Chuanhong¹²,Li Zhiqiang¹²^ORCID

Affiliation:

1. School of Basic Medicine, Qingdao University, Qingdao, China

2. The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes) & the Affiliated Hospital of Qingdao University, Qingdao, China

3. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China

4. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China

Abstract

High doses of cinnamaldehyde induce developmental neurotoxicity in zebrafish, and its toxicological mechanisms may be related to oxidative stress. Astaxanthin can reverse the cinnamaldehyde induced toxic phenotype in zebrafish.

Funder

China Postdoctoral Science Foundation

Taishan Scholar Foundation of Shandong Province

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO02309A

Reference67 articles.