Rapid detection of cancer DNA in human blood using cysteamine-capped AuNPs and a machine learning-enabled smartphone-Reference-Cited by-同舟云学术

Rapid detection of cancer DNA in human blood using cysteamine-capped AuNPs and a machine learning-enabled smartphone

Published:2023 Issue:2 Volume:13 Page:1301-1311
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Koowattanasuchat Sireemas¹,Ngernpimai Sawinee¹,Matulakul Piyaporn¹,Thonghlueng Janpen¹,Phanchai Witthawat¹,Chompoosor Apiwat²,Panitanarak Uthumporn³,Wanna Yupaporn⁴,Intharah Thanapong⁴^ORCID,Chootawiriyasakul Kanokon⁵,Anata Pimjai⁶,Chaimnee Prajuab⁶,Thanan Raynoo⁷,Sakonsinsiri Chadamas⁷^ORCID,Puangmali Theerapong¹^ORCID

Affiliation:

1. Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand

2. Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand

3. Department of Biostatistics, Faculty of Public Health, Mahidol University, Bangkok, 10400, Thailand

4. Department of Statistics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand

5. Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

6. Molecular Diagnosis Unit, Central Laboratory, Srinagarind Hospital, Khon Kaen University, Khon Kaen, 40002, Thailand

7. Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

Abstract

The methylation landscape (Methylscape) of normal and malignant DNAs is different, resulting in unique self-assembly patterns in solution. The dispersion of cysteamine-capped AuNPs adsorbed onto DNA clusters could be employed to identify cancer DNA.

Funder

National Research Council of Thailand

Khon Kaen University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D2RA05725E

Reference55 articles.

1. Towards DNA methylation detection using biosensors

2. Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker