Contrasting reactivity of fluorinated 2,6-heptanediones towards amines and ammonia, leading to cyclohexanediones or 2-oxa-6-azabicyclo[2.2.2]octanes and evaluation of their cytotoxicity-Reference-Cited by-同舟云学术

Contrasting reactivity of fluorinated 2,6-heptanediones towards amines and ammonia, leading to cyclohexanediones or 2-oxa-6-azabicyclo[2.2.2]octanes and evaluation of their cytotoxicity

Published:2019 Issue:26 Volume:43 Page:10537-10544
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Pikun Nadiia V.¹²³^ORCID,Kolesnyk Natalya P.⁴⁵⁶,Rusanov Eduard B.⁴⁵⁶^ORCID,Plotniece Aiva¹²³^ORCID,Sobolev Arkadij¹²³^ORCID,Domracheva Ilona¹²³,Shermolovich Yuriy G.⁴⁵⁶

Affiliation:

1. Latvian Institute of Organic Synthesis

2. Riga

3. Latvia

4. Institute of Organic Chemistry NAS of Ukraine

5. 02660 Kyiv

6. Ukraine

Abstract

Synthesis and cytotoxic studies of cyclohexanediones and 2-oxa-6-azabicyclo[2.2.2]octanes obtained in reaction of fluorinated 2,6-hetanediones with amines and ammonia respectively.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ01446B

Reference29 articles.

1. The role of fluorine in medicinal chemistry

2. Applications of Fluorine in Medicinal Chemistry

3. Fluorination methods for drug discovery and development

4. Selective Synthesis of Fluorine-Containing Cyclic β-Amino Acid Scaffolds

5. Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones

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