Nuclear-targeted nanocarriers based on pH-sensitive amphiphiles for enhanced GNA002 delivery and chemotherapy-Reference-Cited by-同舟云学术

Nuclear-targeted nanocarriers based on pH-sensitive amphiphiles for enhanced GNA002 delivery and chemotherapy

Published:2021 Issue:9 Volume:13 Page:4774-4784
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Li Fan¹²³⁴⁵,Xu Xing¹²³⁴⁵,Liang Yan⁶⁷⁸⁵^ORCID,Li Yan¹²³⁴⁵,Wang Miaochen¹²³⁴⁵,Zhao Fen⁹¹⁰⁴⁵,Wang Xu¹²³⁴⁵,Sun Yong⁶⁷⁸⁵^ORCID,Chen Wantao¹²³⁴⁵^ORCID

Affiliation:

1. Department of Oral and Maxillofacial Head & Neck Oncology

2. Shanghai Ninth People's Hospital

3. Shanghai Jiao Tong University School of Medicine

4. Shanghai

5. China

6. Department of Pharmaceutics

7. Qingdao University School of Pharmacy

8. Qingdao

9. Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology

10. National Clinical Research Center of Stomatology

Abstract

An original pH-sensitive amphiphile that can provide a triple-stage targeted GNA002 delivery was fabricated to precisely deliver GNA002 from the injection site to the nucleus.

Funder

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR07239G

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