Dynamics of the excited-state hydrogen transfer in a (dG)·(dC) homopolymer: intrinsic photostability of DNA-Reference-Cited by-同舟云学术

Dynamics of the excited-state hydrogen transfer in a (dG)·(dC) homopolymer: intrinsic photostability of DNA

Published:2018 Issue:41 Volume:9 Page:7902-7911
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Francés-Monerris Antonio¹²³⁴⁵^ORCID,Gattuso Hugo⁶⁷⁸⁹¹⁰^ORCID,Roca-Sanjuán Daniel¹¹¹²¹³¹⁴^ORCID,Tuñón Iñaki¹⁵¹²¹⁶¹⁴^ORCID,Marazzi Marco¹⁷¹⁸¹⁹²⁰¹⁴^ORCID,Dumont Elise²¹²²²³²⁴²⁵^ORCID,Monari Antonio¹²³⁴⁵^ORCID

Affiliation:

1. Université de Lorraine

2. CNRS

3. LPCT

4. Nancy F-54000

5. France

6. Theoretical Physical Chemistry

7. Research Unit Molecular Systems (UR MOLSYS)

8. University of Liège

9. 4000 Liège

10. Belgium

11. Instituto de Ciencia Molecular

12. Universitat de València

13. ES-46071 Paterna

14. Spain

15. Departamento de Química Física

16. 46100 Burjassot

17. Departamento de Química

18. Centro de Investigación en Síntesis Química (CISQ)

19. Universidad de La Rioja

20. 26006 Logroño

21. Univ. Lyon

22. ENS de Lyon

23. CNRS UMR 5182

24. Université Claude Bernard Lyon 1

25. Laboratoire de Chimie

Abstract

Multiscale molecular dynamics simulations reveal out-of-plane distortions that favour DNA photostability. A novel photostability mechanism involving four proton transfers and triggered by a nearby Na⁺ ion is also unveiled.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C8SC03252A

Reference57 articles.

1. Life in the light: nucleic acid photoproperties as a legacy of chemical evolution

2. Are the five natural DNA/RNA base monomers a good choice from natural selection?