Design, synthesis, and structure–activity relationship studies of 6,7-dihydro-5<i>H</i>-pyrrolo[1,2-<i>b</i>][1,2,4]triazole derivatives as necroptosis inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, and structure–activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors

Published:2024 Issue:7 Volume:15 Page:2514-2526
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Jin Zechen¹²,Dai Yang³²,Ji Yinchun³,Peng Xia³,Duan Wenhu¹²⁴,Ai Jing³²,Zhang Hefeng¹^ORCID

Affiliation:

1. Small-Molecule Drug Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China

2. School of Pharmacy, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China

3. Cancer Research Center, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China

4. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong, 264117, China

Abstract

This study reported a series of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives with potent RIPK1 inhibitory activity and anti-necroptotic activity in both human and mouse cellular assays.

Funder

China Postdoctoral Science Foundation

Chinese Academy of Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00265B

Reference27 articles.

1. 24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis

2. Ripoptocide – A Spark for Inflammation

3. The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

4. RIP1, a kinase on the crossroads of a cell's decision to live or die

5. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death