Chemical fragment-based CDK4/6 inhibitors prediction and web server-Reference-Cited by-同舟云学术

Chemical fragment-based CDK4/6 inhibitors prediction and web server

Published:2016 Issue:21 Volume:6 Page:16972-16981
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Ling¹²³⁴⁵,Li Yecheng¹²³⁴⁵,Xu Mengyan⁶⁷⁸⁴⁵,Pang Xiaoqian¹²³⁴⁵,Liu Zhihong⁶⁷⁸⁴⁵,Tan Wen¹²³⁴⁵,Xu Jun⁶⁷⁸⁴⁵

Affiliation:

1. Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering

2. School of Bioscience and Bioengineering

3. South China University of Technology

4. Guangzhou 510006

5. China

6. Research Center for Drug Discovery

7. School of Pharmaceutical Sciences

8. Sun Yat-Sen University

Abstract

Cyclin-dependent kinases (CDKs), a family of mammalian heterodimeric kinases, play central roles in the regulation of cell cycle progression, transcription, neuronal differentiation, and metabolism.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA23289A

Reference46 articles.

1. Cell cycle, CDKs and cancer: a changing paradigm

2. Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinase 4 (CDK4) and AMPK-Related Kinase 5 (ARK5)

3. To cycle or not to cycle: a critical decision in cancer

4. Cyclin dependent kinase (CDK) inhibitors as anticancer drugs

5. G1 cell-cycle control and cancer

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