Continuous flow synthesis of indoles by Pd-catalyzed deoxygenation of 2-nitrostilbenes with carbon monoxide-Reference-Cited by-同舟云学术

Continuous flow synthesis of indoles by Pd-catalyzed deoxygenation of 2-nitrostilbenes with carbon monoxide

Published:2017 Issue:17 Volume:7 Page:10469-10478
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Glotz Gabriel¹²³⁴⁵,Gutmann Bernhard¹²³⁴⁵^ORCID,Hanselmann Paul⁶⁷⁸,Kulesza Anna⁶⁷⁸,Roberge Dominique⁶⁷⁸,Kappe C. Oliver¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Chemistry

2. University of Graz

3. NAWI Graz

4. 8010 Graz

5. Austria

6. Microreactor Technology

7. Lonza AG

8. Switzerland

Abstract

The palladium-catalyzed cyclization of o-vinylnitrobenzenes employing carbon monoxide as terminal reductant is investigated. The reaction proceeds with 1 to 2 mol% of Pd(OAc)₂ and generates carbon dioxide as the only stoichiometric side-product.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA01087G

Reference63 articles.

1. Indole synthesis: a review and proposed classification

2. Practical Methodologies for the Synthesis of Indoles

3. Rearrangements and ring expansions during the deoxygenation of .beta.,.beta.-disubstituted o-nitrostyrenes

4. Deoxygenation of Nitro Groups by Trivalent Phosphorus. Indoles from o-Nitrostyrenes

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