Improved electrochemical detection of a transthyretin synthetic peptide in the nanomolar range with a two-electrode system integrated in a glass/PDMS microchip

Author:

Faure Mathilde12345,Pallandre Antoine16789,Chebil Syrine12345,Le Potier Isabelle16789,Taverna Myriam16789,Tribollet Bernard12345,Deslouis Claude12345,Haghiri-Gosnet Anne-Marie1101112,Gamby Jean12345

Affiliation:

1. CNRS

2. UMR 8235

3. LISE

4. Paris, France

5. Sorbonne Universités

6. Institut Galien Paris-Sud

7. UMR 8612

8. F-92290 Châtenay-Malabry, France

9. Univ Paris-Sud

10. Laboratoire de Photonique et de Nanostructures

11. UPR20

12. , France

Abstract

Differential pulse voltammetry with a 2-microelectrode set-up in microchip was adapted for quantifying peptide (CBI-PN) involved in the diagnosis of familial transthyretin amyloidosis detected at 0.4 V while the Fe(iii)/Fe(ii) redox couple appears at 0 V.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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